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KMID : 0376219860230040621
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Chonnam Medical Journal
1986 Volume.23 No. 4 p.621 ~ p.626
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An Experimental Study of the Effect of Nimodipine on the Survival of Skin Flaps in Rats
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Abstract
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Skin flap necrosis can be a catastrophe in reconstructive surgery. In recent years, many attempts have been made clinically and experimentally to improve the blood supply in ischemic random pattern flaps. Among them, delay procedure has been ordinarily used in reconstructive surgery. There are various methods in delay procedure. ; surgical delay, pharmacological delay and electrical delay. Although what mechanisms which made delay procedure effective had not been fully explained, Finseth (1978) proposed a new vasodilatation hypothesis, based -on the effect of prolonged vascular smooth muscle relaxation in the precapillary arterioles. Since then, many authors attempted to improve flap survival with pharmacological treatment which was based on the his hypothesis.
This study was carried out to reveal the effectiveness of the pharmacological delay by using the nimopidine which was a calcium antagonist and a potent vasodilator of the cerebral and peripheral vessels.
A total of 20 Sprague Dolly rats was grouped into 2; The control, group 1 treated with saline, and group 2 treated with nimodipine. Each animal had a flap on the back measuring 2x8cm and was observed for the flap survival after one week.
The result was summarized; In random pattern flaps, the mean area of flap survival was 5.4cd for the control and 9.4cd for the flap treated postoperatively with nimodipine.
In conclusion, when the nimodipine was administered systemically, there was a significant improvement on survival of the random pattern flap.
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